| ORIGINAL ARTICLE |
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| Year : 2008 | Volume
: 2
| Issue : 4 | Page : 220-223 |
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Screening of roots of Baliospermum montanum for hepatoprotective activity against paracetamol induced liver damage in albino rats
Raju Ratan Wadekar1, Radhika Sachin Supale1, Kunal Mahesh Tewari1, Kalpana S Patil2, Sunil Satyappa Jalalpure2
1 Department of Pharmacognosy and Phytochemistry, Sinhgad Institute of Pharmaceutical Sciences, Lonavala, Pune - 10, India
2 Department of Pharmacognosy and Phytochemistry, K.L.E.S.'s College of Pharmacy, Belgaum-10, India
Correspondence Address:
Raju Ratan Wadekar
Department of Pharmacognosy and Phytochemistry, Sinhgad Institute of Pharmaceutical Sciences, Lonavala, Pune
India
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DOI: 10.4103/0973-8258.44737
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The objective of the present investigation was to study hepatoprotective activity of alcohol, chloroform and aqueous extract of roots of Baliospermum montanum paracetamol induced liver damage model in rats. Liver damage in rats was produced by paracetamol (2 g/kg, po) in tween 80. Alcohol, chloroform, aqueous extracts of roots of the plant was administered to rats daily for seven days. The biochemical parameters were investigated. Histopathological changes in liver were studied. Concurrently silymarin was used as standard hepatoprotective agent. The results indicated that biochemical changes produced by paracetamol were restored to normal by alcohol, chloroform and aqueous extracts. The alcohol and aqueous extract of roots of Baliospermum montanum showed significant hepatoprotective effect whereas chloroform extract showed moderate hepatoprotective activity against paracetamol induced liver damage model in rats. |
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