| ORIGINAL ARTICLE |
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| Year : 2009 | Volume
: 3
| Issue : 3 | Page : 195-200 |
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Anti-inflammatory and analgesic activities of leaf extract of Wattakaka volubilis (Dreagea volubilis)
Debkumar Nandi1, Shila E Besra2, Sumit Dey1, Suresh Babu3, Adirajan Elango3, Soma Roy2, Sumana Mallick2, Venkatachalam S Giri1, Parasuraman Jaisankar1, Joseph J Vedasiromoni2
1 Medicinal Chemistry Division, Indian Institute of Chemical Biology (A Unit of Council of Scientific & Industrial Research), Kolkata-700032, India
2 Environmental Science Programme, Jadavpur University, Kolkata-700032, India
3 Drug Development Division, Indian Institute of Chemical Biology (A Unit of Council of Scientific & Industrial Research), Kolkata-700032, India
Correspondence Address:
Joseph J Vedasiromoni
Drug Development Division, Indian Institute of Chemical Biology, 4, Raja S.C.Mullick Road, Kolkata-700032
India
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DOI: 10.4103/0973-8258.56273
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Wattakaka volubilis (Family: Asclepiadaceae) has been reported to possess medicinal effects. In the present study, the dried leaf extract [methanol-water (1:1)] of W. volubilis designated as 'the extract' was evaluated for pharmacological activity in rats and mice. The anti-inflammatory activity was evaluated using acute, sub-chronic and chronic models of inflammation in rodents. The antipyretic and analgesic activities were evaluated in mice models. In the acute toxicity study, it was found that the extract was non-toxic up to 1 g/kg, i.p. The extract (50, 100 and 200 mg/kg, i.p.) was found to possess, anti-inflammatory, analgesic and antipyretic activities in a dose-dependent manner and the effect was comparable with that produced by the standard drug, ibuprofen. The extract significantly inhibited the arachidonic acid-induced paw oedema in rats, indicating that the extract inhibited both the cyclo-oxygenase and lipo-oxygenase pathways of arachidonic acid metabolism. The extract also significantly enhanced the macrophage count in mice in a dose- and time-dependent manner. It is possible that the saponins present in the extract may be responsible for these activities. |
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