| ORIGINAL ARTICLE |
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| Year : 2009 | Volume
: 3
| Issue : 3 | Page : 206-210 |
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Pharmacological effects of methanolic extract of Swietenia mahagoni Jacq (meliaceae) seeds
Sruti Ghosh1, Shila E Besra2, Kunal Roy3, Jayanta K Gupta3, Joseph R Vedasiromoni2
1 Medicinal Chemistry Department, BCDA College of Pharmaceutical Technology, Jessore Road, Kolkata-700127, India
2 Drug Development Division, Indian Institute of Chemical Biology, 4, Raja S.C. Mullick Road, Kolkata-700032, India
3 Department of Pharmaceutical Sciences, Jadavpur University, Kolkata-700032, India
Correspondence Address:
Joseph R Vedasiromoni
Drug Development Department, Indian Institute of Chemical Biology, 4, Raja S.C. Mullick Road, Kolkata - 700032
India
DOI: 10.4103/0973-8258.56275
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Seeds of medicinal plants are common ingredients of many folk and herbal medicines, and seed extracts have been reported to possess pharmacological activity including anti-inflammatory activity. In the present investigation, the methanolic extract of the dried ground seeds of Swietenia mahagoni (SMSE) has been evaluated for anti-inflammatory, analgesic, and antipyretic activities. The anti-inflammatory activity was evaluated using acute, sub-chronic, and chronic models of inflammation in rodents. The antipyretic and analgesic activities were evaluated in mice models. Acute toxicity studies revealed that the extract up to a dose of 1.2 g/kg intraperitoneally was nontoxic. SMSE at doses of 50 and 100 mg/kg, i.p. was found to possess anti-inflammatory, analgesic, and antipyretic activities and the effect was comparable with that produced by the standard drug, ibuprofen. The results of the experiment on arachidonic acid-induced paw edema in rat revealed that the extract produces anti-inflammatory activity through dual inhibition of the cyclo-oxygenase and lipo-oxygenase pathways of arachidonic acid metabolism. SMSE also enhanced peritoneal cell exudates along with macrophage significantly. The triterpenoids present in SMSE may be responsible for these activities. SMSE possesses anti-inflammatory, analgesic, and antipyretic activities. |
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