Antimigraine activity study of Moringa oleifera leaf juice

Kanchan P. Upadhye, Vinod D. Rangari, Vijay B. Mathur


Background: Migraine is characterized by a pulsating headache, usually restricted to one side, which comes in attacks lasting for
4‑48 hours. Before the headache some of the patients also may experience visual disturbances called ‘aura’. The attacks are also
associated with nausea, vomiting and sensitivity to light and sound. Aim: The aim of the present investigation was to explore the antimigraine potential of alcoholic fraction of leaf juice of Moringa oleifera Lamm, which is traditionally used in the treatment of migraine. Materials and Methods: Three animal models, viz, Apomorphine induced climbing behavior; l‑5‑HTP induced syndrome and MK 801 induced hyperactivity were used to carry out the antimigraine activity studies. Statistical Analysis: The results were analyzed with ANOVA followed by Dunnett’s multiple comparison tests. P<0.05 is considered significant. Prism 5 was used for the statistical analysis. Results and Conclusion: Moringa oleifera significantly reduced the Apomorphine induced climbing behavior, l‑5‑HTP induced syndrome and MK 801 induced hyperactivity in a dose dependent manner. These results indicated that Moringa
oleifera may be acting via dopaminergic and serotonergic receptors. It could be concluded that Moringa oleifera may be effectively used in the treatment or management of migraine.
Key words: Apomorphine, l‑5‑HTP, migraine, MK 801, Moringa oleifera

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