Aqueous extract of Kadarpassi Chooranam: Exploring its novel potential as a siddha drug with acute and repeated dose toxicity effects

J. V. Sabari Anandh


Aims and Objectives: The study aims to evaluate the acute and repeated dose toxicity effects of aqueous extract of
Kadarpassi Chooranam (AEKPC). Materials and Methods: As per the OECD guidelines 425 and 408, acute and
repeated dose toxicity studies were carried out. In the acute toxicity study, a single dose of AEKPC at 2000 mg/kg
was administered p.o to female Wistar rats and in a repeated-dose toxicity study, AEKPC was administered p.o
at 3 different doses (1000, 500, and 250 mg/kg body weight) to both male and female Wistar albino rats for
28 days. At the end of the acute toxicity study, the animals were euthanized and observed for morphological and
pathological changes. In the case of repeated-dose toxicity, the histopathological, hematological, and biochemical
parameters were assessed. Results: The acute toxicity study showed that AEKPC at 2000 mg/kg did not exhibit
any behavioral changes, signs of toxicity, or lethality. The 28-day repeated dose toxicity study also did not produce
any significant signs of toxicity or changes in behavioral parameters. No significant changes in the cellular, as
well as non-cellular components of the blood were observed. Hematological, biochemical profile, and histological
reports indicated that the test formulation did not produce any severe changes at lower doses in contrast, mild-tomoderate
changes were observed at higher doses, and the same was reverted during the recovery period 2 weeks
following discontinuation of the drug. Conclusion: The acute toxicity study report showed that AEKPC was
found to be safe to be administered up to a dose of 2000 mg/kg. In the 28 days of the repeated-dose study, even at
dose levels of 1000 mg/kg, no significant toxic effects were observed.

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