Compressional characteristics and drug release profile of tablets of the crude leaves extract of Vernonia galamensis

Musa Autamashih, Adamu B. Isah, Teriyila S. Allagh


Tablet formulation of the crude aqueous extract of the leaves of Vernonia galamensis (Asteraceae), used for the treatment of diabetes in folk medicine was carried out using the wet granulation method. The dried extract is deliquescent in nature; therefore, efflorescent diluents were carefully selected for the formulation. The purpose of this study was to establish suitable diluents for the formulation of Vernonia galamensis tablets and to study the compressional characteristics and drug release profile. The efflorescent diluents were; calcium phosphate (Hopkins and Williams, UK), Aerosil® 200 (GmbH, Meggle, Germany) and Avicel® PH 101 (FMC Corporation,
USA). The dissolution times of tablets were determined as specified in BP 2007. Heckel analysis was used for compaction studies, tensile strength for mechanical strength and dissolution time for drug release studies. GraphPad Prism® version 5.03 software was used for statistical analysis. Negative intercepts were a major limitation to the use of Heckel analysis, but good quality tablets of the deliquescent crude extract of Vernonia galamensis (Asteraceae) with acceptable release profile could be formulated using calcium phosphate as diluent and polyvinylpyrrolidone (5%, w/v) as binder at a compression pressure of 290 MNm–2.
Key words: Compressibility, dissolution, Heckel equation

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