Antioxidant and pharmaceutical potential of Clerodendrum L.: An overview
Abstract
traditional usage or use as alternative medicine for the treatment of various diseases.
Key words: Antioxidant, Clerodendrum, flavonoids, pharmaceutical, phenolics, steroids, terpenoids
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Plotkin MJ. Traditional knowledge of medicinal plants‑ the search
for new jungle medicine. Cambridge: Cambridge University Press;
p. 245‑6.
Ahmad I, Aqil F, Owais M. Modern phytomedicine: Turning
medicinal plants into drugs. Weinheim: WILEY‑VCH Verlag
GmbH and Co; 2006.
Singh MK, Khare G, Iyer SK, Sharwan G, Tripathi DK. Clerodendrum
serratum: A clinical approach. J Appl Pharm Sci 2012;2:11‑5.
Hoareau L, DaSilva EJ. Medicinal plants: A re‑emerging health
aid. Electron J Biotechnol 1999;2:3‑4.
Fay MF. Conservation of rare and endangered plants using in vitro
methods. In Vitro Cell Devl Biol Plant 1992;28:1‑4.
Heywood VH, Heenan PB, Brummitt RK, Culham A, Seberg O.
Flowering plant families of the world. N Z J Bot 2008;46:103.
Cantino PD, Harley RM, Wagstaff SJ. Genera of Labiatae status
and classification. In: Advances in Labiate Science. In: Harley RM,
Reynolds T, editors. Kew: Royal Botanical Gardens; 1992. p. 511‑22.
Wagstaff SJ, Olmstead RG. Phylogeny of labiatae and verbenaceae
inferred from rbcL sequences. Syst Bot 1997;22:165‑79.
Cronquist A. An integrated system of classification of flowering
plants. Columbia: Columbia University Press; 1981.
Jiofack T, Fokunang C, Guedje N, Kemeuze V, Fongnzossie E,
Nkongmeneck BA, et al. Ethnobotanical uses of some plants of
two ethnoecological regions of Cameroon. Afr J Pharm Pharmacol
;3:664‑84.
Chowdhury JU, Nandi NC, Bhuiyan MN. Chemical composition of
leaf essential oil of Lantana camara L. from Bangladesh. Bangladesh
J Bot 2007;36:193‑4.
Siegler DS. Plant secondary metabolism. United States: Kluwer
Academic Publishers; 1998. p. 337‑405.
Shrivastava N, Patel T. Clerodendrum and heathcare: An overview.
Med Aromat Plant Sci Biotechnol 2007;1:142‑50.
Moldenke HN. Notes on the genus Clerodendrum (Verbenaceae).
Phytologia 1985;57:334‑65.
Rueda RM. The genus Clerodendrum (Verbenaceae) in Mesoamerica.
Ann Mo Bot Gard 1993;870‑90.
Hsiao JY, Lin ML. A chemotaxonomic study of essential oils from
the leaves of genus Clerodendrum (Verbenaceae) native to Taiwan.
Bot Bull Acad Sinica 1995;36:247‑51.
Steane DA, Scotland RW, Mabberley DJ, Olmstead RG. Molecular
systematics of Clerodendrum (Lamiaceae): ITS sequences and total
evidence. Am J Bot 1999;86:98‑107.
Rajendran A, Dniel P. The Indian Verbenaceae: A taxonomic
revision. Dehradun: Bishen Singh Mahendra Pal Singh; 2002.
Srivastava RC, Choudhary RK. Species diversity and ecocomic
important of the family verbenaceae in Arunachal Pradesh. Bull
Arunachal Forest Res 2008;24:1‑21.
Hazekamp A, Verpoorte R, Panthong A. Isolation of a bronchodilator
flavonoid from the Thai medicinal plant Clerodendrum petasites.
J Ethnopharmacol 2001;78:45‑9.
Kang DG, Lee YS, Kim HJ, Lee YM, Lee HS. Angiotensin converting
enzyme inhibitory phenylpropanoid glycosides from Clerodendron
trichotomum. J Ethnopharmacol 2003;89:151‑4.
Panthong A, Kanjanapothi D, Taesotikul T, Wongcome T,
Reutrakul V. Anti‑inflammatory and antipyretic properties of
Clerodendrum petasites S. Moore. J Ethnopharmacol 2003;85:151‑6.
Choi JH, Whang WK, Kim HJ. Studies on the anti‑inflammatory
effects of Clerodendron trichotomum Thunberg leaves. Arch Pharm
Res 2004;27:189‑93.
Kanchanapoom T, Chumsri P, Kasai R, Otsuka H, Yamasaki K.
A new iridoid diglycoside from Clerodendrum chinense. J Asian
Nat Prod Res 2005;7:269‑72.
Rehman AU, Begum S, Saied S, Choudhary MI, Akhtar F.
A steroidal glycoside from Clerodendron inerme. Phytochemistry
;45:1721‑2.
Kanchanapoom T, Kasai R, Chumsri P, Hiraga Y, Yamasaki K.
Megastigmane and iridoid glucosides from Clerodendrum inerme.
Phytochemistry 2001;58:333‑6.
Chourasiya RK, Jain PK, Jain SK, Nayak SS. Agrawal RK. In vitro
antioxidant activity of Clerodendron inerme (L.) Gaertn leaves, Res
J Pharm Biol Chem Sci 2010;1:119‑23.
Gurudeeban S, Satyavani K, Ramanathan T, Umamaheshwari G,
Shanmugapriya R. Antioxidant and radical scavenging effect of
Clerodendrum inerme (L). World J Fish Mar Sci 2010;2:66‑9.
Singh VP, Sharma SK, Khan VS. Medicinal plants from Ujain
district Madhya Pradesh part II. Indian Drugs Pharm Ind
;5:7‑12.
Chaturvedi GN, Subramaniyam PR, Tiwari SK, Singh KP.
Experimental and clinical studies on diabetic mellitus
evaluating the efficacy of an indigenous oral hypoglycaemic
drug‑arani (Clerodendron phlomidis). Anc Sci Life 1983;3:216‑24.
Khan MA, Singh VK. A folklore survey of some plants of
Bhopal district forests, Madhya Pradesh, India, described as
antidiabetics. Fitoterapia 1996;67:416‑21.
Cheng HH, Wang HK, Ito J, Bastow KF, Tachibana Y, Nakanishi Y,
et al. Cytotoxic pheophorbide‑related compounds from
Clerodendrum calamitosum and C. cyrtophyllum. J Nat Prod
;64:915‑9.
Chae S, Kim JS, Kang KA, Bu HD, Lee Y, Seo YR, et al. Antioxidant
activity of isoacteoside from Clerodendron trichotomum. J Toxicol
Environ Health A 2005;68:389‑400.
Yang H, Jiang B, Hou AJ, Lin ZW, Sun HD. Colebroside A, a new diglucoside of fatty acid ester of glycerin from Clerodendrum
colebrookianum. J Asian Nat Prod Res 2000;2:177‑85.
Praveen M, Radha K, Hari Kumar R, Padmaja V, Mathew A, Ajith
Kumar P. Preliminary phytochemical, antimicrobial and toxicity
studies on Clerodendrum paniculatum Linn leaves. Hygeia J D Med
;4:41‑50.
Jun T, Handong S. Chemical constituents of Clerodendrum indicum.
Nat Prod Res Dev 1999;11:1‑5.
Pandey R, Verma RK, Gupta MM. Pentadecanoic acid
beta‑D‑glucoside from Clerodendrum inerme. Indian J Chem
;45:2161.
Gokani RH, Rachchh MA, Patel TP, Lahiri SK, Santani DD,
Shah MB. Evaluyion of antioxidant activity (in vitro) of
Clerodendrum phlomidis, Linn. F. Suppl. Root. J Herb Med Toxicol
;5:47‑53.
Bhattacharjee D, Das A, Das SK, Chakraborthy GS. Clerodendrum
Infortunatum Linn.: A review. J Adv Pharm Healthcare Res
;1:82‑5.
Nan HH, Zhang S, Wu J. Chemical constituents from Clerodendrum
inerme. Chinese Tradit Herb Drugs 2005;4:1‑4.
Jun T, Dong SH. Chemical constituents from Clerodendrum
japonicum. Acta Bot Yunnanica 1995;17:103‑8.
Hui Y, Hou AJ, Mei SX, Sun HD, Che CT. Constituents of
Clerodendrum bungei. J Asian nat prod res 2002;4:165‑9.
Taiz L, Zeiger E. Plant physiology. Sunderland, Massachusett,
Sinauer Associates, Inc. Tanksley SD and McCouch, SR (1997). Seed
banks and molecular maps: Unlocking genetic potential from the
wild. Science 1998;277 :1063‑6.
Jaya Babu G, Naidu KC, Ganapaty S. Phytochemical examination
of the stem of Clerodendrum serratum (L) Moon. Indian Drugs
;34:208‑10.
Joshi KC, Singh P, Mehra A. Chemical investigation of the roots
of different Clerodendron species. Planta Med 1979;37:64‑6.
Singh R, Singhi CL. Chemical investigations of Clerodendrum
fragrans. J Indian Chem Soc 1981;58:626‑7.
Prakash L, Garg G. Chemical constituents from the stem heartwood
of Guazuma Tomentosa. J Indian Chem Soc 1981;58:726‑7.
Akihisa T, Matsubara Y, Ghosh P, Thakur S, Tamura T,
Matsumoto T. Sterols of some Clerodendrum species (verbenaceae):
Occurence of the 24‑α and 24‑β epimers of 24‑ethylsterols lacking
a delta 25‑bond. Steroids 1989;53:625‑38.
Akihisa T, Matsubara Y, Ghosh P, Thakur S, Shimizu N,
Tamura T, et al. The 24‑α and 24‑β‑ epimers of 24‑ Ethylcholesta‑5,
‑diene‑3β‑ol in two Clerodendrum species. Phytochem
;27:1169‑72.
Singh R, Prakash L. Chemical examination of stems of Clerodendrum
inerme (L) Gaertn. (Verbenaceae). Pharmazie 1983;38:565.
Parveen M, Khanam Z, Ali M, Rahman SZ. A novel lupene‑type
triterpenic glucoside from the leaves of Clerodendrum inerme. Nat
Prod Res 2010;24:167‑76.
Rao LJ, Periera, Gurudutt KN. Neo cleorodane diterpenes from
Clerodendrum inerme, Phytochem 1993;34:572‑4.
Lin YL, Kuo YH, Chen YI. Two new clerodane‑type diterpenoids,
clerodinins A and B from Clerodendrum brachyanthum Schauer.
Chem Pharm Bull 1989;37:2192‑3.
Lammel G, Rimpler H. Iridoids in Clerodendrum thomsonae balf F.,
Verbenaceae. Z Naturforsch C 1981;36:708‑13.
Sannigrahi S, Mazumder UK, Pal D, Mishra SL. Terpenoids of
methanol extract of Clerodendrum infortunatum exhibit anticancer
activity against Ehrlich’s ascites carcinoma (EAC) in mice. Pharm
Biol 2012;50:304‑9.
Goyal AK, Basistha BC, Sen A, Middha SK. Antioxidant profiling
of Hippophae salicifolia growing in sacred forests of Sikkim, India.
Funct Plant Biol 2011;38:697‑701.
Halliwell B. Free radicals and antioxidants: A personal view. Nutr
Rev 1994;52:253‑65.
Mishra T, Goyal AK, Middha SK, Sen A. Antioxidative properties
of Canna edulis Ker‑Gawl. Indian J Nat Prod Res 2011;2:315‑21.
Ismail Shareef M, Leelavathi S. Evaluation of antioxidant activity
of Anisolmeles malabarica R Br and Clerodendrum serratum L. Extracts
against rheumatism. Res J Pharm Biol Chem Sci 2011;2:488‑95.
Modi AJ, Khadabadi SS, Deore SL, Kubde MS. Antioxidant effects
of leaves of Clerodendrum infortunatum (Linn.). Int J Pharm Sci Res
;1:67‑72.
Priyesh P, Narayanasamy VB, Manjunatha Setty M, shirwaikar
A. Antioxidant potential of Clerodendron viscosum vent. Roots.
Pharmacol Online 2007;2:226‑35.
Sathish M, Tharani CB, Niraimathi V. Free radical scavenging activity
of various extracts from root of Clerodendrum Phlomidis (Linn.)
evaluated by three in vitro methods. Res J Pharm Biol Chem Sci
;2:752‑61.
Rajurkar BM. A comparative study on antimicrobial activity of
Clerodendrum infortunatum, Simarouba glauca and Proralea cortlifolia.
Int J Res Rev Pharm Appl Sci 2011;1:278‑82.
Tamta M, Kumar A, Shukla N, Negi D. Effects of crude extracts of
Premna barbata Wall and Clerodendrum viscosum Vent. (Verbenaceae)
on different pathogenic bacteria. Asian J Trad Med 2012;7:1‑7.
Oly WT, Islam W, Hassan P, Parween S. Antimicrobial activity
of Clerodendrum viscosum (Verbenaceae). Intl J Agric Biol
;13:222‑6.
Khan AV, Khan AA. Antibacterial potential of Clerodendrum inerme
crude extracts against some human pathogenic bacteria. Ethnobot
Leaf 2005;1:1‑6.
Chahal JK, Sarin R, Malwal M. Efficacy of Clerodendrum inerme
L. (garden quinine) against some human pathogenic strains. Int J
Pharm Bio Sci 2010;1:219‑23.
Anitha R, Kannan P. Antifungal activity of Clerodendrum inerme (L).
and Clerodendrum phlomidis (L). Turk J Biol 2006;30:139‑42.
Joseph J, Bindhu AR, Aleykutty NA. Antimicrobial activity of
Clerodendrum paniculatum Linn. Leaves. Int J Res Ayurveda Pharm
;2:1003‑4.
Venkatanarasimman B, Rajeswari T, Padmapriya B. Antibacterial
potential of crude leaf extract of Clerodendrum philippinum schauer.
Int J Pharm Bio Arch 2012;3:307‑10.
Abouzid SF, Wahba HM, Elshamy A, Cos P, Maes L, Apers S, et al.
Antimicrobial activity of some Clerodendrum species from Egypt.
Nat Prod Res 2013;27:1032‑6.
Yankanchi SR, Koli SA. Anti‑inflammatory and analgesic activity
of mature leaves methanol extract of Clerodendrum inerme
L. (Gaertn). J Pharm Sci Res 2010;2:782‑5.
Das S, Haldar PK, Pramanik G, Suresh RB. Evaluation of
anti‑inflammatory activity of Clerodendron infortunatum Linn.
extract in rats. Global J Pharmacol 2010;4:48‑50.
Surendrakumar P. Anti‑inflammatory activity of Lippia nodiflora,
Clerodendrum phlomidis and Delonix elata. J Res Educ Indian Med
;7:19‑20.
Parekar RR, Dash KK, Marathe PA, Apte AA, Rege NN. Evaluation
of anti‑inflammatiry activity of root bark of Clerodendrum phlomidis
in experimental models of inflammation. Intl J Appl Biol Pharm
Technol 2012;3:54‑60.
Zailani AH, Balogun EA, Adebayo JO. Ethanolic extract of
Clerodendrum violaceum Gurke leaves enhances kidney function
in mouse model of malaria. Indian J Exp Biol 2009;47:349‑54.
Deressa T, Mekonnen Y, Animut A. In vivo anti‑malarial
activities of Clerodendrum myricoides, Dodonea angustifolia and
Aloe debrana against Plasmodium berghei. Ethiop J Health Dev
;24:25‑9.
Simonsen HT, Nordskjold JB, Smitt UW, Nyman U, Palpu P,
Joshi P, et al. In vitro screening of Indian medicinal plants for
antiplasmodial activity. J Ethnopharmacol 2001;74:195‑204.
Gayar F, Shazli A. Toxicity of certain plants to Culex pipiens larvae.
Bull Soc Entomol Egypt 1986;52:458‑67.
Kalyanasundaram M, Das PK. Larvicidal and synergestic
activity of plant extracts for mosquito control. Indian J Med Res
;82:19‑23.
Pandey R, Yadav SK, Gupta SK. Anti‑diabetic activity of
Clerodendrum (or Clerodendron) inerme using in vivo and in vitro
studies. Nov Sci Int J Pharm Sci 2012;1:298‑302.
Choi SW, Benzie IF, Ma SW, Strain JJ, Hannigan BM. Acute
hyperglycemia and oxidative stress: Direct cause and effect? Free
Radic Biol Med 2008;44:1217‑31.
Manoharan S, Kavitha K, Balakrishnan S, Rajalingam K.
Clerodendron inerme protects cellular integrity during 7,
‑dimethylbenz [A]‑anthracene induced hamster buccal pouch
carcinogenesis. Afr J Tradit Complement Altern Med 2008;5:213‑22.
Chinchali JF, Sanakal RD, Kaliwal BB. Evaluation of anticarcinogenic
activity of Clerodendrum serratum leaf extract on liver and kidney
of 7, 12 dimethylbenz [a] anthracene (DMBA) induced skin
carcinogenesis in mice. Eur J Exp Biol 2011;1:130‑41.
John J, Mathew AJ, Setty MM. Free radical scavenging and
anticancer activity of Clerodendrum paniculatum. Pharmacol online
;3:730‑43.
Vijayamirtharaj R, Vincent S, Senthilkumar N. Analgesic activity
of Clerodendrum phlomidis Linn. (Aerial parts). Int J Res Pharm
Biomed Sci 2011;2:120‑3.
Das JK, Kandar CC, Dey SP, Mandal SC. Evaluation of analgesic
activity of Clerodendrum viscosum Linn. (Verbenaceae) leaves on
experimental animal model. Int J Pharm Bio Sci 2011;2:345‑9.
Chandrashekar R, Rao SN. acute central and peripheral analgesic
activity of Ethanolic Extract of the leaves of Clerodendrum
viscosum (EECV) in rodent models. J Drug Deliv Ther 2012;2:105‑8.
DOI: https://doi.org/10.22377/ijgp.v8i4.415
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