Screening of roots of Baliospermum montanum for hepatoprotective activity against paracetamol induced liver damage in albino rats

Raju Ratan Wadekar, Radhika Sachin Supale, Kunal Mahesh Tewari, Kalpana S. Patil, Sunil Satyappa Jalalpure


Th e objective of the present investigation was to study hepatoprotective activity of alcohol, chloroform and aqueous extract of roots of Baliospermum montanum paracetamol induced liver damage model in rats. Liver damage in rats was produced by paracetamol (2 g/kg, po) in tween 80. Alcohol, chloroform, aqueous extracts of roots of the plant was administered to rats daily for seven days. Th e biochemical parameters were investigated. Histopathological changes in liver were studied. Concurrently silymarin was used as
standard hepatoprotective agent. Th e results indicated that biochemical changes produced by paracetamol were restored to normal by alcohol, chloroform and aqueous extracts. Th e alcohol and aqueous extract of roots of Baliospermum montanum showed signifi cant hepatoprotective eff ect whereas chloroform extract showed moderate hepatoprotective activity against paracetamol induced liver damage model in rats.
Key words: Baliospermum montanum, hepoatoprotective, paracetamol, silymarin

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Chatt erjee TK. Options. Calcutt a: Books and Allied (P) Ltd; 2000.

p. 155.

Bhandarkar M, Khan A. Antihepatotoxic eff ect of Nymphaea stellata

Willd against Carbon tetrachloride hepatic damage in albino rats.

J Ethnopharmacol 2004;91:61-4.

Lee KJ, Woo ER, Choi CY. Protective effect of acetoside on

carbon tetrachloride induced hepatotoxicity. J Sci 2004;74:


Handa SS, Kapoor VK. International book of pharmacognosy. New

Delhi: Vallabh Prakashan; 1989. p. 125.

Varies PS. In: Medicinal plants-A compendium of 500 species.

Madras: Orient Longman Ltd; 1994. p. 240-3.

Chaterjee A, Prakashi SC. In: Treatise on Indian Medicinal Plants.

New Delhi: CSIR; 1994. p. 24-9.

Harborne JB. In: Methods. London: Chapman and Hall; 1998.

p. 52.

OECD guidelines for the testing of chemicals, Revised Draft

Guidelines Acute Oral Toxicity-Acute Toxic Class Methods 2000.

p. 423.

Baheti JR, Goyal RK. Hepatoprotective activity of Hemidesmus

indicus in rats. J Exp Biol 2006;44:399-402.

Reitman S, Frankel S. A colorimetric methods for the determination

of serum glutamic oxaloacetate and glutamic pyruvic transaminase.

J Clin Pathol 1957;28:28-56.

Suresh SV, Sujatha C, Syamala J, Nagasudha B, Mishra SH.

Protective eff ect of root extract of Operculina turpenthum Linn.

against Paracetamol induced hepatotoxicity in rats. Indian J

Pharma Sci 2006;68:32-5.

Sanford B. In: Science and practice of pharmacy. Easton: Mack

Publishing Company; 1995. p. 111.

Minamide Y, Horie T, Awazu S. High molecular weight protein

aggregates formed in the liver of the rat following large doses of

paracetamol. J Pharma Pharmacol 1992;44:932-4.



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