Antioxidants in skin ageing – Future of dermatology

Shamika M. Salavkar, Rashmi A. Tamanekar, Rajani B. Athawale


The formation of free radicals is a widely accepted pivotal mechanism leading to skin ageing. Skin ageing is a complex, progressive,time-dependent deterioration caused by intrinsic and extrinsic factors or environmental factors. Skin is equipped with an elaborate antioxidant system that protects it from oxidative damage due to intrinsic and extrinsic factors. However, the natural antioxidant pool can be compromised or overwhelmed by oxidative stress of excess UV exposure, as well as cigarette smoke and other airborne pollutants. Topical antioxidants have been demonstrated to protect the skin from free radical damage and its regular application can actually reverse pervious photodamage. Topical antioxidants are available in over-the-counter skin care products that are aimed at preventing the clinical signs of photoageing. The present review summarises scientific literature regarding efficacy of topical
antioxidants and significance of novel delivery systems for topical antioxidant delivery for combating skin ageing.
Key words: Antioxidants, novel drug delivery systems, skin ageing, topical delivery

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