Encouraging effect of Brahmi Ghrita in amnesia

Kapil Deo Yadav, K. R. C. Reddy, Vikas Kumar


Context: Brahmi Ghrita (BG) contains Brahmi (Bacopa monneri), Vacha (Acorus calamus), Kushtha (Saussurea lappa),
Shankhapushpi (Convolvulus pluricaulis) and Puran Ghrita, prepared as per sneha paka process. Aim: The aim of this study was to assess the learning and memory activity of BG in Amnesic rats. Materials and Methods: The Learning and memory activity of BG (400 and 800 mg/kg, per oral) was evaluated in scopolamine (1 mg/kg, sub cutaneous) challenged rats, using elevated maze plus, passive avoidance test and active avoidance test. Results: BG treated scopolamine challenged rat demonstrated a significant decrease in transfer latency in modified elevated plus maze test and increase in step through latency in passive avoidance test compared to
control rats in a dose dependent manner. BG treated rats took significant less number of total trials, shock trial and total time for jumping into safe compartment. Conclusion: BG antagonises the action of scopolamine.
Key words: Brahmi Ghrita, modified elevated plus maze test, scopolamine

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DOI: http://dx.doi.org/10.22377/ijgp.v7i2.308


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