Hepatoprotective activity of Trianthema decandra on carbon tetrachloride-induced hepatotoxicity in rats
Abstract
total protein and albumin in serum. Th e aqueous extract of Trianthema decandra roots (50 mg, 100 mg and 200 mg/kg) were orally administered to the animals with hepatotoxicity induced by carbon tetrachloride and its eff ects on biochemical parameters were compared with Silymarin (25 mg/kg) treated animals. Trianthema decandra (100 and 200 mg/kg) results in a signifi cant reduction in serum hepatic enzymes when compared to rats treated with carbon tetrachloride alone. Th ere was a signifi cant increase in the serum total protein and albumin when compared to rats treated with carbon tetrachloride alone. Th e results concludes that the aqueous extract of Trianthema decandra roots (100 and 200 mg/kg) has protected the liver from carbon tetrachloride-induced damage.
Key words: Carbon tetrachloride, hepatoprotective and silymarin, Trianthema decandra
Full Text:
PDFReferences
Warrier PK, Nambiar VP, Ramankutt y C. Indian medicinal plants
a compendium of 500 species. vol. 1. India: Orient Longman Pvt
Ltd; 1994. p. 349-51.
Nadkarni KM. Indian materia medica. vol. 1. 3rd ed. Mumbai:
Popular Prakashan Pvt Ltd; 1996. p. 1228.
Javed A, Farooqui AH, Sageer A. Trianthema portulacastrum L an
herbal drug for the cure of edema. J Herbs Species Med Plants
;7:65-70.
Kumar G, Sharmila BG, Vanitha PP, Sundrarajan M,
Rajasekarapandian M. Hepatoprotective activity of Trianthema
portulacastrum L against paracetamol and thioacetamide
intoxication in albino rats. J Ethanopharmacol 2004;92:37-40.
Kumar G, Sharmila Banu G, Rajasekarapandian M. Evaluation of
the antioxidant activity of Trianthema portulacastrum L. Indian J
Pharmacol 2005;37:331-3.
Ecobichon DJ. The basis of toxicology testing. New York: CRC
Press; 1997. p. 43-86.
Rao PG, Rao SG, Kumar V. Effect of hepatoguard against
carbon tetrachloride induced liver damage in rats. Fitoterapia
;64:108-13.
Gupta M, Mazumder UK, Sambath Kumar R. Hepatoprotective
and antioxidant role of Caesalpinia bonducella on paracetamol
induced liver damage in rats. Nat Prod Sci 2003;9:186-91.
Gowenlock AH, McMurray JR, McLauchlan DM. Plasma proteins.
In: VarleyÂ’s Practical Clinical Biochemistry. 6th ed. New Delhi: CBS
Publishers; 1988. p. 401-35.
Johnson DE, Kroening C. Mechanism of early Carbon tetrachloride
toxicity in cultured rat hepatocytes. Pharmacol Toxicol
;83:231-9.
Lim HK, Kim HS, Choi HS, Oh S, Choi J. Hepatoprotective eff ects
of bergenin, major constituent of Mallotus japonicus on CCl4
intoxicated rats. J Ethanopharmacol 2000;72:469-74.
Hayes JR, Londie LW, Leeca BJ. Acute 14 days repeated dosage and
dayssubchronic toxicity studies of CCl4 in CDI mice. Fundam
Appl Toxicol 1986;7:454.
Subramoniam A, Pushpangadan P. Development of phytomedicines
for liver diseases. Indian J Pharmacol 1999;31:166-75.
Burtes CA, Ashwood ER. Text book of clinical chemistry.
Philadelphia: WB Sunders Co; 1986. p. 56.
Mandal PK, Bishayee A, Chatterjee M. Studies of hepatic
protein synthesis in response to Mikania cordate root extract
in CCl4 induced hepatotoxicity in mice. Ital J Biochem
;431:345-50.
Sengottuvelu, et al.: Hepatoprotective activity of Trianthema decandra on carbon tetrachloride-induced hepatotoxicity in rats
DOI: https://doi.org/10.22377/ijgp.v2i2.45
Refbacks
- There are currently no refbacks.
 | |
About us | Contact us | Sitemap | Advertise | What's New | Feedback | Copyright and Disclaimer | Â |
© 2014 International Journal of Green Pharmacy | Hosted and Maintained by BRNSS Publication Hub | |
Online since 15th February, 2008 www.brncop.org | www.asiapharmaceutics.info | www.aiip.info | |
 |