Evaluation of antioxidant and antiparkinsonian activities of Brassica oleracea in haloperidol‐induced tardive dyskinesia

Asst Prof. S. Nagarjuna

Abstract


Background: Brassica oleracea is a leafy green vegetable commonly called as cabbage. It belongs to the family Brassicaceae.Studies reveal that it is rich in flavonoids and has high antioxidant property. Aims: The present study was aimed at evaluating
antiparkinsonian activity of B. oleracea in haloperidol‐induced tardive dyskinesia. Settings and Design: The present study was
designed for 14 days administration of the plant extract then behavioral and biochemical parameters were estimated in the rats.
Materials and Methods: B. oleracea was collected, dried in the shade, powdered, and subjected to the extraction by cold maceration using water and methanol mixture of H2O/CH3OH as a solvent. The extract was subjected to preliminary phytochemical screening. Haloperidol model was selected for screening antiparkinsonian activity, and it was administered at a dose of 1 mg/kg i.p., for 14 days. Behavioral and biochemical parameters were estimated in all the groups. Statistical Analysis Used: Statistical significance between more than two groups was tested using one‐way ANOVA followed by the Bonferroni’s compare all columns test using the computer‐based fitting program. Results: In groups treated with hydroalcoholic extract of B. oleracea (250 and 500 mg/kg p.o.,) decreased the elevated levels of lipid peroxidation in the haloperidol‐treated animals and elevated the cellular defense mechanisms such as glutathione, further suggesting the role of free radicals in the pathophysiology of the haloperidol‐induced extrapyramidal syndrome.

Conclusion: This study reveals the use of B. oleracea in parkinsonian disease.

Key words: Behavioral parameters, biochemical parameters, Brassica oleracea, haloperidol, parkinsonian disease


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DOI: http://dx.doi.org/10.22377/ijgp.v9i3.451

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