Effects of Biskhapra (Trianthema portulacastrum Linn.) leaves extract in adriamycin induced nephrotic syndrome

Abstract

Trianthema portulacastrum popularly known as Biskhapra, is a well documented drug, used for various kidney ailments, although no scientific evidence is available. The animals were divided into 7 groups of 10 animals each, i.e. plain, negative A and B, and two preand post-treated groups. Plain control treated with distilled water only and adriamycin (7.5 mg/kg) was administered to other groups. Negative A and B group were left untreated for 10 and 30 days, respectively, while pre- and post-treated groups were administered test drug in a dose of 450 and 900 mg/kg before and after the administration of adriamycin, respectively, for 20 days. Adriamycin
produces proteinuria, increases the serum cholesterol, creatinine, blood urea nitrogen (BUN), and decreases the serum albumin
and protein. Therefore, these parameters were taken into account along with histopathological changes in kidney. Test drug reduced the serum cholesterol, creatinine and BUN, and increased the serum albumin and protein levels. Histopathological examination revealed remarkable changes in negative control groups, which were corrected in all the test groups. Test drug has preventive as well as curative effect in adriamycin-induced nephrotic syndrome and is in consonance with the reports of Unani literature regarding its
use in renal disorders.
Key words: Hydroalcoholic extract, minimal change nephropathy, preventive and curative effect, unani medicine, wistar rats