In vitro and In vivo anti-inflammatory potential of isolated compounds from ethyl acetate extracts of Tecomaria capensis

Abstract

Aim: The leaves of the plant Tecomaria capensis were extracted with different solvents and screened for anti-inflammatory activity. Materials and Methods: The ethyl acetate extract of the plant T. capensis has showed the presence of flavonoids, glycosides, steroids, and terpenoids. Anti-inflammatory activity was investigated by carrageenan-induced method (in vivo) for isolated compounds from ethyl acetate extract of T. capensis leaves. Results and Discussion: The in vitro anti-inflammatory activity of the 3, 4 dihydro-2,2 dimethyl-2H-benzochromene-5,6 dione and (3R)-3,7-dimethyloct-6-en-1-ol was concentration dependent. While in in vivo, the percentage reduction in the paw volume calculated at 3rd h for 3,4 dihydro-2,2 dimethyl-2H-benzochromene-5,6 dione was 54.5%, (3R)-3, 7-dimethyloct-6-en-1-ol was 77.3%, and standard diclofenac was 79.6%. Conclusion: This study demonstrates that isolated compounds of ethyl acetate extract of T. capensis have significant anti-inflammatory activities.