Lagenaria siceraria: A nutraceutical for good health

Charu Katare, Supriya Agrawal, Seema Rana, Shweta Sharma, Shilpa Chauhan, GBKS Prasad


Background: Health education is the essential requirement for the empowerment of developing India. It is the physical, mental,
social and nutritional well being of the person. Health and plant foods have an age‑old association. Several plant foods are reported to have nutraceutical functions. Lagenaria siceraria (bottle gourd) is reported to have several health benefits and hence may be used as a nutraceutical also. Aim: To assess the beneficial effect of bottle gourd juice on biochemical parameters of normal healthy subjects. Materials and Methods: 200 ml freshly prepared Lagenaria siceraria fruit extract (LSFE) was administered every day at fasting state early in the morning to normal healthy subjects. Anthropometric measurements, fasting blood sugar levels, lipid profile, antioxidant status and kidney and liver functions markers were monitored at the beginning and at the end of the 3 months of therapy. Results:
Analysis of the data using t‑test revealed that there was significant improvement at P<0.05 level in triglycerides (TG), High‑Density Lipoprotein‑Cholesterol (HDL‑c) and Very Low‑density Lipoprotein‑Cholesterol (VLDL‑c) levels. A considerable decrease in risk ratio for heart disease was also observed. There was 3.9% reduction in blood glucose level. A marked improvement in antioxidant status was seen. A significant improvement in kidney function at P<0.05 level in urea and uric acid was found. Liver function markers
showed significant reduction at P<0.001 level in bilirubin levels. Conclusion: Findings of the study indicated that LSFE administration may act as a nutraceutical for disease prevention and favour good health
Key words: Antioxidant, health, bottle gourd, Lagenaria siceraria, lipid lowering, nutraceutical

Full Text:



UNESCO. Culture and Health, Orientation Texts –World Decade

for Cultural Development 1988‑1997, Document CLT/DEC/PRO –

, Paris, France: UNESCO; 1996. p. 29.

Sidhu K, Kaur J, Kaur G, Pannu K. Prevention and cure of Digestive

Disorders Through the Use of Medicinal Plants. J Hum Ecol


Korver O. Functional foods: The food industry and functional

foods: Some European perspectives. In: Shibamoto T, Terao J,

Osawa T, editors. Functional Foods for Disease Prevention,

II. Medicinal Plants and Other Foods. Washington, DC: American

Chemical Society; 1998. p. 22‑5.

Ghule BV, Ghante MH, Saoji AN, Yeole PG. Hypolipidemic and

antihyperlipidemic effects of Lagenaria siceraria (Mol.) fruit extracts.

Indian J Exp Biol 2006;44:905‑9.

Deshpande JR, Mishra MR, Meghre VS, Wadodkar SG, Doerle AK.

Free radical scavenging activity of Lagenaria siceraria (Mol.) Standl,

Fruit. Nat Prod Radiance 2007;6:127-30.

Raabo E, Terkildsen TC. On the enzymatic determination of blood

glucose. Scand J Clin Lab Invest 1960;12:402‑7.

Fossati P, Prencipe L. Serum triglycerides determined

colorimetrically with an enzyme that produces hydrogen peroxide.

Clin Chem 1982;28:2077‑80.

Stockbrige H, Hardy RI, Glueck CJ. Public cholesterol screening:

motivation for participation, follow‑up outcome, self‑knowledge

and coronary heart disease risk factor intervention. J Lab Clin Med


Lopes‑virella MF, Stone P, Ellis S, Colwell JA. Cholesterol

determination in high‑density lipoproteins separated by three

different methods. Clin Chem 1977;23:882‑4.

Berthelot MPE. Report. Chim Appl 1859;2884:217‑84.

Fossati P, Prencipe L, Berti G. Use of 3,5-dichloro-2-

hydroxybenzenesulfonic acid/4‑aminophenazone chromogenic

system in direct enzymic assay of uric acid in serum and urine.

Clin Chem 1980;26:227‑31.

Jendrassik L, Grof P. Colorimetric method for estimation of serum

bilirubin. Biochemistry 1938;2297:81.

Tietz. In: Textbook of Clinical Chemistry. 3rd ed. Philadelphia: W.B.

Saunders Company; 1999. p. 617‑721.

Winterbourn CC, Hawkins RE, Brian M, Carrell RW. The

estimation of red cell superoxide dismutase activity. J Lab Clin

Med 1975;85:337‑41.

Sinha AK. Colorimetric assay of catalase. Anal Biochem


Ellman GL. Tissue sulfhydryl groups. Arch Biochem Biophys


Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal

tissues by thiobarbituric acid reaction. Anal Biochem 1979:


Lowry OH, Roesborough NJ, Farr AL, Randall KJ. Protein

measurement with folin phenol reagent. J Biol Chem


Ayensu ES. Endangered plants used in traditional medicine and

health coverage. Geneva: WHO; 1983. p. 342.

Zheng J, He J, Ji B, Li Y, Zhang X. Antihyperglycemic effects of

Platycodon grandiflorum (Jacq) A. DC extract on streptozotocininduced

diabetic mice. Plant Foods Hum Nutr 2007;62:7‑11.

Nainwal P, Nandal D, Tripathi S. Reduction in blood cholestrol

level using the hydroalcoholic extract of fruits of Lagenaria siceraria.

Int J Res Pharm Biomed Sci 2011;2:110‑3.

Rachh PR, Rachh MR, Modi DC, Shah BN, Bhargava AS. In vitro

Evaluation of Antioxidant Activity of Punarnava (Boerhaavia

diffusa Linn.). Int J Pharm Res 2009;1:36‑40.

Ford ES, Giles WH, Dietz WH. Prevalence of the metabolic

syndrome among US adults: findings from the third National

Health and Nutrition Examination Survey. JAMA 2002;


Marie CV. Effects of high‑fat and Chlorella vulgaris feeding

on changes in lipid metabolism in mice. Biologia Bratislava


Deore SL, Khadabadi SS, Patel QR, Deshmukh SP, Jaju MS,

Junghare NR, et al. In vitro antioxidant activity and quantitative

estimation of phenolic content of Lagenaria siceraria. Rasayan J

Chem 2009;2:129‑32.



  • There are currently no refbacks.