Sub‑acute toxicity of a hydro‑ethanolic whole plant extract of Synedrella nodiflora (L) Gaertn in rats

Samuel Adjei, Patrick Amoateng, Dorcas Osei Safo, Clement Sasu, Benoit Banga N’guessan, Phyllis Addo, Julius Isaac Asiedu Gyekye

Abstract


Objectives: Synedrella nodiflora (L) Gaertn (family Asteraceae) is traditionally used in Ghana for the management of epilepsy,
hiccup and threatened abortion. The anticonvulsant and other related neuro‑pharmacological effects of a hydro‑ethanolic extract in murine models have been established. To this end, we evaluated a sub‑acute toxicity of the hydro‑ethanolic whole plant extract in rats. Materials and Methods: The effects of a continuous 14‑day oral administration of the extract (100, 300 and 1000 mg/kg) on haematological and serum biochemical parameters were measured.

Results: The extract produced no mortality in the rats treated during the study period. The extract also did not significantly affect any of the haematological and serum biochemical indices measured.
Conclusion: This result suggests that a 14‑day oral administration of the hydro‑ethanolic extract of Synedrella nodiflora is relatively safe in Sprague‑Dawley male rats under the present laboratory conditions.
Key words: Male rats, sub‑acute toxicity, Synedrella nodiflora


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DOI: http://dx.doi.org/10.22377/ijgp.v8i4.425

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