Effect of non steroidal anti-inflammatory drugs on inhibition of nitrite-induced methemoglobin formation

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DOI: https://doi.org/10.22377/ijgp.v2i4.6

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P. B. Miniyar
S. S. Toshniwal
R. S. Toshniwa
S. U. Deoda
S. J. Makhija

Abstract

Paracetamol, Diclofenac, Aceclofenac, Nimesulide, Ibuprofen and Rofecoxib belonging to the class of non-steroidal anti-infl ammatory
drugs (NSAID’s) were tested for inhibitory role on nitrite-induced oxidation of hemoglobin in vitro. Result indicates a promising
inhibitory role of aceclofenac and signifi cant inhibitory role of ibuprofen in a concentration range of 0.25 mM each. Pro-oxidant activity was higher for remaining test compounds viz., Diclofenac, Paracetamol, Rofecoxib and Nimesulide.
Key words: Free radical, methemoglobin, nitrite, NSAID

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Vol. 2 No. 4 (2008): Oct-Dec

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