Formulation and evaluation of embelin emulgel for topical delivery

Abstract

Background: Embelin is an isolated compound from Embelia ribes and well known for its potent antioxidant and anti-inflammatory properties. However, so far, embelin has not been explored into a topical dosage form due to its hydrophobic nature. Emulgel is a recently developed formulation and emerged as a promising topical delivery system for the delivery of hydrophobic drugs. Aim: The aim of the study to formulate emulgel of embelin and tested for its antioxidant and anti-inflammatory properties. Materials and Methods: The emulsion was prepared and incorporated in a gel base. The formulations were evaluated for physicochemical properties and tested for in vitro antioxidant activity using 2, 2-Diphenyl-1-picrylhydrazyl method. The formulated emulgels were also tested for inhibition of albumin denaturation and lipoxygenase inhibition to evaluate its in vitro anti-inflammatory activity. Results and Discussion: Both the formulated Emulgels (F1 and F2) were looks a purple creamy with a smooth homogeneous texture and glossy appearance. The formulated embelin emulgel showed potent antioxidant and moderate anti-inflammatory properties that is water soluble gel. Conclusion: This embelin emulgel will be further developed into a commercial standard and tested for in vivo studies to confirm its anti-inflammatory properties.