Compressional characteristics and drug release profile of tablets of the crude leaves extract of Vernonia galamensis

Musa Autamashih, Adamu B. Isah, Teriyila S. Allagh

Abstract


Tablet formulation of the crude aqueous extract of the leaves of Vernonia galamensis (Asteraceae), used for the treatment of diabetes in folk medicine was carried out using the wet granulation method. The dried extract is deliquescent in nature; therefore, efflorescent diluents were carefully selected for the formulation. The purpose of this study was to establish suitable diluents for the formulation of Vernonia galamensis tablets and to study the compressional characteristics and drug release profile. The efflorescent diluents were; calcium phosphate (Hopkins and Williams, UK), Aerosil® 200 (GmbH, Meggle, Germany) and Avicel® PH 101 (FMC Corporation,
USA). The dissolution times of tablets were determined as specified in BP 2007. Heckel analysis was used for compaction studies, tensile strength for mechanical strength and dissolution time for drug release studies. GraphPad Prism® version 5.03 software was used for statistical analysis. Negative intercepts were a major limitation to the use of Heckel analysis, but good quality tablets of the deliquescent crude extract of Vernonia galamensis (Asteraceae) with acceptable release profile could be formulated using calcium phosphate as diluent and polyvinylpyrrolidone (5%, w/v) as binder at a compression pressure of 290 MNm–2.
Key words: Compressibility, dissolution, Heckel equation

Full Text:

PDF

References


Allagh TS, Ameh GO, Okafor IS. Formulation and evaluation of

the physicochemical properties of (Fam asteraceae) granules and

tablets. Nig J Pharm Sc 2009;8:18-25.

Ilic I, Kasa P, Dreu R, Pintye-Hodi K, Sircic S. The compressibility

and compactibility of different types of lactose. Drud Dev Ind

Pharm 2009;35:1271-80.

Ismi CY, Nasipuri RN, Ojile JB, Ibrahim YKE, Emeje M. Effects

of the diluent type on compressional characteristics of the mixed

stem bark extract of Anogeissus leiocarpus and Prosopis africana

tablet formulation. Acta Pharm 2003;53:49-56.

Odeku OA. Assessment of Albizia zygia gum as a binding agent

in tablet formulation. Acta pharm 2005;55:263-76.

Heckel RW. An analysis of powder compaction phenomena. Trans

Metall Soc AIME 1961;222:1001-8.

Kunle OO, Nasipuri RN, Oyewumi MO, Ojile JE, Wambebe CN.

Formulation studies on the hot water leaf extract of Ficus sur

(Moraceae): Compaction characteristics and effect of magnesium

stearate on granule and tablet properties. Acta Pharm 1999;49:

-99.

Fell T, Newton JM. Determination of tablet strength by the

diametral compression test. J Pharm Sci 1970;59:688-91.

Hersey JA, Rees JE. Deformation of Particles During Briquetting, in

Proceedings of the 2nd Particle Size Analysis Conference. Bradford:

Society for Analytical Chemistry 1970. p. 33.

York P, Pilpel N. The tensile strength and compression behavior of

lactose, four fatty acids and their mixtures in relation to tableting.

J Pharm Pharmacol 1973;25:1-11.

Ebube NK, Mark W, Hahm H. Preformulation studies and

characterization of proposed chondroprotective agents:

Glucosamine Hcl and chondroitin sulfate. Pharm Dev Tec

;7:457-69.

Paroren P, Juslin M. Compression characteristic of four starches.

J Pharm Pharmacol 1983;35:627-35.

Odeku OA, Itiola AO. Evaluation of khaya gum as a binder in

a paracetamol tablet formulation. Pharm Pharmacol Commun

;4:183-8.

Hyunjo K, Gopi V, Fassihi R. Compatibility characterization of

granular fraction for Tableting using a compaction simulator. Int

J Pharm 1998;161:149-59.

Emeje M, Isimi C, Kunle O. Effect of Grewia gum on the mechanical

properties of paracetamol tablet formulations. Afr J Pharm

Pharmacol 2008;2:2001-6.

Capan Y. Influence of technological factors on formulation of

sustained release tablets Drud Dev Ind Pharm 1989;15:925-57.

Gonul N, Ogan-Hascicek C, Baykara T. The consolidation and

compressibility proiperties of some novel directly compressible

filler-binders. Acta Poloniac Pharm Drug Res 2000;57:311-17.

Sonnergaard JM. A critical evaluation of the Heckel equation. Int

J Pharm 1999;193:63-71.

Sebhatu T, Ahlneck C, Alderborn G. The effect of moisture content

on the compression and bond-formation properties of amorphous

lactose particles. Int J Pharm 1997;146:101-14.

Itiola OA. Compression characteristics of three starches and the

mechanical properties of their tablets. Pharm World J 1991;8:91-4.

Gar JS, Robinstein MH. Direct compression characteristics of

Xylitol. Int J Pharm 1990;64:223-6.




DOI: http://dx.doi.org/10.22377/ijgp.v5i1.171

Refbacks

  • There are currently no refbacks.