Investigation of phytochemicals and anti‑convulsant activity of the plant Coleus amboinicus (lour.)

Prasenjit Bhattacharjee, Pulak Majumder

Abstract


Objectives: The present study has been designed to evaluate the comparative anticonvulsant activity of different parts of Coleus amboinicus as it has been mentioned in the various literatures regarding the use of this plant in the treatment of epilepsy, but no specific scientific reports are available in this regard. Materials and Methods: The in vitro anticonvulsant activity of leaf, stem and roots of C. amboinicus has been evaluated by maximal electric shock‑induced seizures (MES) and Pentylenetetrazole (PTZ)‑induced seizures models in Swiss albino mice. The drug/extracts were administered through intra‑peritoneal route (100 mg/ml), in both experimental
models and the effect was compared with Phenytoin in MES and PTZ‑induced convulsion. Results: All the three studied extracts
have shown significant anticonvulsant activity in both the models. However, the alcoholic leaf extract has shown highest activity by
abolishing the MES‑induced convulsions after 60 minutes of drug administration. The duration of convulsions in PTZ model was
also significantly reduced (P < 0.001) compared to the control group. Conclusion: The alcoholic leaf extract of the C. amboinicus has shown the significant anticonvulsant activity in both the studied models, followed by stem and root extracts. The presence of alkaloids, flavonoids, and saponins in these extracts may be responsible for this activity.
Key words: Anti‑convulsant, Coleus amboinicus, maximal electric shock, Pentylenetetrazole, Phenytoin

Full Text:

PDF

References


Anonymous. The Wealth of India: Raw Materials. II. Publications

and Information Directorate. New Delhi: CSIR; 1950. p. 308.

Warrier PS. Indian Medicinal Plants. Arya vaidya sala. Kottakkal:

Orient Longmann Ltd; 1994. p. 315‑7.

Chopra RN, Nayar SL, Chopra IC. The Glossary of Indian

Medicinal Plants. New Delhi: CSIR Publications; 1956. p. 74‑5.

Kirtikar KR, Basu BD. Indian Medicinal Plants, 2nd ed. Dehradun:

International Book Distributors; 1975. p. 971.

Nadkarni AK. Indian Materia Medica, 2nd ed. Mumbai: Popular

Prakashan; 1996. p. 371.

Ragasa CY, Sangalang V, Pendon Z. Antimicrobial flavones from

Coleus amboinicus. Philipp J Sci 1999;128:347‑51.

Pritima RA, Selvaraj R, Pandian RS. Antimicrobial activity of Coleus

aromaticus (Benth) against microbes of reproductive tract infections

among women. Afr J Infect Dis 2008;1:18‑24.

Kathiresan RM. Allelopathic potential of native plants against

water hyacinth. Crop Prot 2000;19:705‑8.

Rastogi RP, Mehrotra BN. Compendium of Indian Medicinal

Plants. Lucknow: CDRI and New Delhi: Publication and

Information Directorate; 1979. p. 201.

Neelam B, Mayuren C, Sateesh K. Screening of anti‑inflammatory

activity of Coleus aromaticus. Int J Chem Sci 2009;7:2384‑8.

Khandelwal KR. Practical Prarmacognosy. 19th ed. 2008:149‑53.

Achliya GS, Wadodkar SG, Darle AK. Evaluation of CNS activity

of Bramhi Ghrita. Indian J Pharmacol 2005;37:33‑6.

Yemitan OK, Salahdeen HM. Neurosedative and muscle relaxant

activities of aqueous extract of Bryophyllum pinnatum. Fitoterpia

;76:187‑93.

Salahdeen HM, Yemitan OK. Neuropharmacological effects of

aqueous leaf extract of Bryophyllum pinnatum in mice. Afr J Biomed

Res 2006;9:101‑7.

Rang HP, Dale MM, Ritter JM. Pharmacology, 5th ed. Edinburgh:

Churchill Livingstone; 2003. p. 552‑3.

White SH, Roger JP, David C. The Epilepsies, 2nd ed. 1997. p. 485‑7.

Ma cdo n a l d RL, Twyman RE, Rya n ‑ J a strow T.

Anticonvulsant activity of the aqueous leaf extract of Croton

Zambesicus (Euphorbiaceae) in mice and rats. Epilepsy Res

Suppl 1992;9:265‑77.

Mc Donald RL, Oslen RW. GABAA receptor channels. Annu Rev

Neuro Sci 1994;17:569‑602.

McNamara JO. Drugs effective in therapy of the epilepsies. In:

Hardman JG, Limbird LC, Gilman AG, editors. Goodman and

Gilman’s the Pharmacological Basis of Therapeutics, 10th ed.

New York: McGraw‑Hill; 2001. p. 521‑47.

Yoganarasimhan SN. Medicinal plants of India. Vol 1. Karnataka.

p. 564.

Sebastian PF, Cristina W, Alejandro C, Paladini MM. Central

nervous system depressant action of flavonoid glycosides. Eur J

Pharmacol 2005;11:512:189‑98.




DOI: http://dx.doi.org/10.22377/ijgp.v7i3.325

Refbacks

  • There are currently no refbacks.