Quality control evaluation of Guduchi Satva (solid aqueous extract of Tinospora cordifolia (Willd.) Miers): An herbal formulation

Rohit Sharma, Hetal Amin, V. J. Shukla, Dhiman Kartar, R. Galib, P. K. Prajapati

Abstract


Introduction: Herbal products represent complex biological mixture and achieving a reproducible pharmaceutical quality could be a very challenging task in standardisation of herbal products. Hence, methodical approach is required for standardisation, development of sufficient quality control profile and scientific validation of plant extracts, as is done in contemporary medicine. Ayurvedic physicians
prescribe dried extract of Tinospora cordifolia (Willd.) Miers known as ‘Guduchi Satva’ in several febrile conditions. However, till today no published information is available on its analytical profile. Aims and Objectives: Present study is aimed to evaluate quality control parameters for Guduchi Satva. Materials and Methods: Fifteen batches of Guduchi Satva were prepared and findings were systematically recorded. Physicochemical parameters and qualitative tests for various functional groups, quantitative estimation of total alkaloids, fluorescence analysis, high performance thin layer chromatography (HPTLC) profile, heavy metal analysis and microbial load of Guduchi Satva were carried out. Results: The average percentage of dried Satva obtained was 3.8%. Alkaloids, carbohydrates and starch were found present in Satva. Number of peaks obtained in HPTLC also corresponds to this finding. Percentage of total
alkaloid content was 0.31%. No heavy metal and microbial load were detected in the sample. The present observation can be considered as standard for further studies on Satva.
Key words: Guduchi, quality control, Satva, Tinospora cordifolia

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DOI: http://dx.doi.org/10.22377/ijgp.v7i3.332

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