Comparative study of antitoxin activity of Calotropis gigentea Linn and Cassia fistula Linn against Naja-naja (cobra) venom
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Abstract
dried leaves of Calotropis gigantea Linn and Cassia fistula Linn was tested for haemolysis, procoagulant, oedema-forming activity
against cobra (Naja-Naja) venom. The hydroalcoholic extract showed a significant inhibitory effect on haemolysis, procoagulant,
oedema-forming activity. Calotropis gigantea Linn extract was significantly neutralize Naja-naja venom as compared to Cassia fistula Linn in a dose dependent manner. The present study suggests that hydroalcoholic extract of dried leaves of Calotropis gigantea Linn and Cassia fistula Linn possess compounds, which neutralize the activity of cobra (Naja-Naja) venoms.
Key words: Oedema forming, hemolysis, Naja-naja, procoagulant
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