Nephroprotective effects of ethanolic extract of Sesamum indicum seeds (Linn.) in streptozotocin induced diabetic male albino rats

Palanisamy Bhuvaneswari, Shanmugasundaram Krishnakumari


Background: Hyperglycaemia is the important hallmark of Diabetes mellitus and it is the world’s most common endocrine disorder. The aim of the present study was to evaluate the effect of ethanolic extract of Sesamum indicum (Linn.) on kidney function in Streptozotocin Nicotinamide induced diabetic rats. Materials and Methods: Twenty four Wistar albino rats of 200-250 g each were grouped into 4 groups with six rats in each group (control, diabetic, diabetic treated and standard drug -glibenclamide treated). After treatment for 8 weeks, the animals were sacrificed and the biochemical parameters like serum total protein, albumin and globulin, urea, uric acid and creatinine were measured for the evaluation of kidney damage. Results: STZ-induced diabetic rats showed a significant decrease in the levels of serum total protein, albumin and globulin and significant increase in the levels of blood urea, serum
creatinine and uric acid when compared to normal rats. These levels were reverted after the treatment regimen. Conclusion: Fromthe study, the Sesamum indicum extract administration to the diabetic rats resulted in normalizing the marker enzymes in serum and the histopathological results also reveal the protective effect of the plant extract. The above results shows that the ethanolic extract of Sesamum indicum seeds has a potential effect to control hyperglycemia in streptozotocin induced diabetic rats.
Key words: Creatinine, diabetes, histopathology, sesamum indicum, urea, uric acid

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